Yes, Options+ is compatible with macOS Universal Control. But there are a few limitations as described below:

1. When Universal Control is used to switch from Computer A to Computer B, your Logitech devices are not physically connected to Computer B. So, any configuration you have for your device via Options+ will not work in Computer B. Your device will work as it would if Options+ were not installed. For your device configuration in computer B to work, you will need to connect to computer B directly or using our Flow feature. 
2. If the Flow feature is set up between the two computers and Universal Control is enabled, Universal control takes precedence and Flow doesn’t work. To use Flow, please disable Universal Control.