While the majority of Bose receivers are compatible with Harmony remotes, a few older Bose receivers are only controllable using an RF (radio frequency) remote control and are not compatible with a Harmony remote. Some Bose receivers can, through the use of a third-party adapter be controlled by a Harmony remote.

Bose models that are compatible with a Harmony remote but may require set up change to IR (see Bose user manual for instructions, or Knowledge Base article 360023394313:

• Lifestyle 18 (AV18 or AV28 Media Center)
• Lifestyle 28 (AV18 or AV28 Media Center)
• Lifestyle 35 (AV18 or AV28 Media Center)
• Lifestyle 38 (AV38 Media Center)
• Lifestyle 48 (AV48 Media Center)
• Lifestyle V10 (MC-1 Media Console)
• Lifestyle V20 (MC-1 Media Console)
• Lifestyle V30 (MC-1 Media Console)
• 3-2-1 GS Home Entertainment System
• 3-2-1 GSX Home Entertainment System

Bose models that require the Audio Authority C-1024A Home Theater System Controller for Legacy Bose Lifestyle Systems in order to be controllable by a Harmony remote:

• Lifestyle 20 (CD20 Media Center)
• Lifestyle 25 (CD20 Media Center)
• Lifestyle 30 (CD20 Media Center)
• Lifestyle 40 (M1 Multi-Room Interface)
• Lifestyle 50 (M1 Multi-Room Interface)
• Bose models that are not controllable by a Harmony remote:
• Lifestyle 5 (Model 5 Media Center)
• Lifestyle 8 (Model 5 Media Center)
• Lifestyle 10
• Lifestyle 11
• Lifestyle 12 (Model 5 Media Center)
• Lifestyle 800
• Lifestyle 900
• All Wave series