Some games have separate .exe files for single player and multiplayer modes. For these games, each .exe file needs its own profile.
NOTE: Before you proceed, make sure either the single player or multiplayer mode has an existing, working profile. If you need help getting a profile to work, see answer 360023245934.
To create a new profile for the other game mode:
Open the Logitech Gaming Software:
Start > All Programs > Logitech > Logitech Gaming Software 8.x
Click the glowing G-Keys.
Click the down arrow under the "+" and select "Create New Profile."
Enter a name that identifies the profile and then click the "…" button by the "Select Game Executable" option.
Browse to the directory of the game, select the game .exe and then click Open.
NOTE: The game's install location shown below may not be the same as your system. If you're unsure of the location of the correct .exe file, see answer 360023245934 for help.
Select the "Copy from an existing profile" check box and then choose the profile that works for the other game mode.
Click OK to finish setting up your new profile.
NOTE: Profiles may share the same name. In the image above, both BlackOps.exe and BlackOpsMP.exe have the profile name "Call of Duty: Black Ops". You can also use a different name, like "Call of Duty: Black Ops (MP)" for the multiplayer BlackOpsMP.exe.
You should now have a new profile for the other game mode with all of your customizations carried over from the original.