Logitech Presentation and Presentation Lite supports several Microsoft Windows and Apple macOS presentation applications, and can both detect and start a presentation depending on the application.
The following applications and functions are currently supported by Logitech Presentation and Presentation Lite.
| Application | Detect Presentation mode | Can Start Presentation | Comments |
| PowerPoint 2019 | Yes | Yes | |
| PowerPoint 2016 | Yes | Yes | |
| PowerPoint 2010 | Yes | Yes | |
| PPT Office 365 online (Chrome) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| PPT Office 365 online (Firefox) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| PPT Office 365 online (Edge) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| PPT Office 365 online (IE 11) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| Adobe Reader 17 | Yes | Yes | |
| Adobe Reader 16 | Yes | Yes | |
| Adobe Reader latest DC (cloud version) | Yes | Yes | |
| Google Slides (Chrome) | Yes | Yes | |
| Google Slides (Firefox) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| Google Slides (Edge) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| Google Slides (IE 11) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| Application | Detect Presentation mode | Can Start Presentation | Comments |
| PowerPoint 2019 | Yes | Yes* | For Mac OS X - * Using custom Keystroke - Select Custom Keystroke and add 1. To Play slide show from the first slide COMMAND + SHIFT+ RETURN 2. Play slide show from the current slide, COMMAND + RETURN |
| PowerPoint 2016 | Yes | Yes* | For Mac OS X - * Using custom Keystroke - Select Custom Keystroke and add 1. To Play slide show from the first slide COMMAND + SHIFT+ RETURN 2. Play slide show from the current slide, COMMAND + RETURN |
| PowerPoint 2010 | Yes | Yes* | For Mac OS X - * Using custom Keystroke - Select Custom Keystroke and add 1. To Play slide show from the first slide COMMAND + SHIFT+ RETURN 2. Play slide show from the current slide, COMMAND + RETURN |
| PPT Office 365 online (Chrome) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| PPT Office 365 online (Firefox) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| PPT Office 365 online (Safari) | Yes | No* | * no existing shortcut to start PowerPoint Online presentation |
| Keynote (latest available) | Yes | Yes | |
| Preview (latest available) | Yes | Yes* | * might need a mouse click to ensure focus is on the slide |
| Google Slides (Safari) | Yes | Yes* | * might need a mouse click to ensure focus is on the slide |
| Google Slides (Chrome) | Yes | Yes* | * might need a mouse click to ensure focus is on the slide |
| Google Slides (Firefox) | Yes** | Yes* | * might need a mouse click to ensure focus is on the slide ** full screen needed, otherwise, cannot distinguish from edit mode (and thus, cannot start it with Next button long press) |
| Adobe Reader 17 | Yes | Yes | |
| Adobe Reader 16 | Yes | Yes | |
| Adobe Reader latest DC (cloud version) | Yes | Yes |
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