This error screen occurs when a setting for an Activity, like an input selection, or which device is used to change channels is not properly selected.

Solution

Run the Activity wizard, one at a time, for all of your Activities.

1. Launch the Logitech Harmony Remote software and login to your account
2. From the Harmony homepage, select the first Activity listed and click on the button for it
   

   

3. Select Review the settings for this Activity and click on the button

   

4. Select No, I want to run the setup wizard again to change these settings and click on the button

   

5. Move through the wizard by clicking on the Next button to move to the next page, ensuring that all questions have been answered correctly. Usually a setting will be unselected, causing the error
   

   

6. Repeat for every Activity in your account, attempting to update each time to check if the error has been corrected