If you're having trouble with profile detection, you may not have the profile associated with the correct or active game .exe file.
To find the active .exe for a game, you can either:
Associate automatically using a G-Series keyboard with an LCD screen (see 360023244634).
Find the .exe through Windows Task Manager (see 360023244634).
NOTE: You only need to do one of the above if the profile isn't associated correctly. If you can point to the correct .exe when creating a profile, you don't need to do either one.