Connect video and audio will work with any application that supports the Universal Video Class (UVC) standard, which is pretty much any video conferencing application.  Once the device is recognized by your operating system, the application will in turn automatically recognize the camera, microphone and speaker from the Connect.  
 
A partial list of applications that support Connect include Skype for Business, Microsoft Teams, Zoom, Google Hangouts, BlueJeans, Vidyo, Gotomeeting, WebEx and dozens of others.