This issue is most likely configuration related. Check the mouse button and program settings in Logitech's Mouse and Keyboard software (SetPoint).
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Open SetPoint (Start > Programs > Logitech > Mouse and Keyboards > Mouse and Keyboard Settings).
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Click on the My Mouse tab on the top of the SetPoint window.
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Click on the Mouse Button Settings icon on the left side of the SetPoint window.
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Select VX Revolution from the Select Mouse drop-down menu.
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Select the program that the button is not working on in the Select Program area.
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Click on a button that needs verification in the Select Button area.
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Verify the task intended for that button in the Select Task area.
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Click OK when you are done.
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