You can configure your gaming keyboard separately for each game or application on your computer (see 360023244954 for instructions). When a game is launched, the profile associated with it should activate. Sometimes, the profile doesn't activate properly, which can prevent game-specific settings from being applied.
When a game profile isn't activating properly:
Try using a Persistent Profile (see answer 360023244954 for instructions).
NOTE: Using a persistent profile will help you determine if the Logitech Gaming Software is working properly.
Make sure the correct .exe file is selected for the game (see answer 360023244954 for help).
Check that both the single player and multiplayer .exe files have profiles (see answer 360023244954 for help).